- http://www.birmingham.ac.uk/welcome/grab.aspx
- http://en.wikipedia.org/wiki/Eugenie_Scott
- http://ncse.com/
- http://en.wikipedia.org/wiki/Kenneth_R._Miller
- http://johnhawks.net/
- http://pathogenomics.bham.ac.uk/staff/mpallen.html
- http://en.wikipedia.org/wiki/Randal_Keynes
- http://www.birmingham.ac.uk/index.aspx
- http://www.english-heritage.org.uk/daysout/properties/home-of-charles-darwin-down-house/
An eclectic blog on evolution & Darwiniana Any opinions are mine, not my publisher's
Written by Mark Pallen.
The book Rough Guide to Evolution,
given to 6000 students via Great Read at Birmingham.
My other blog: bacterial pathogenomics
Sunday, September 25, 2011
Visiting Down House with Randal Keynes
Saturday, September 24, 2011
Ken Miller at the opening Great Read at Birmingham event

The Evolution Wars: Why they continue, Why they matter, by Ken Miller
See also:
- http://en.wikipedia.org/wiki/Kenneth_R._Miller
- http://www.findingdarwinsgod.com/
- http://en.wikipedia.org/wiki/Kitzmiller_v._Dover_Area_School_District
- http://www.birmingham.ac.uk/welcome/grab.aspx
- http://pathogenomics.bham.ac.uk/staff/mpallen.html
- http://www.amazon.co.uk/Rough-Guide-Evolution-Science-Phenomena/dp/1858289467/
Thursday, September 8, 2011
Great Read at Birmingham

The idea behind the the Great Read at Birmingham initiative was proposed by the Vice-Chancellor, Professor David Eastwood, and is based on many successful similar programmes run in North America. But no British university has ever implemented a programme on this scale before!
There will be University-wide activities around the book during Welcome Week and the first term. Schools and departments will also use the book in study skills modules or in other ways.
Thursday 22 September 2011 15:30-17:00
As part of the Great Read at Birmingham initiative, "Rough Guide to Evolution" author Professor Mark Pallen welcomes two great speakers on evolution to our University, speaking back to back in Welcome Week in the Barber Institute Concert Hall.
This is open only to students at @uniBirmingham. Limited spaces available. First come, first served!
NATURAL SELECTION, NEANDERTHAL GENOMES AND THE MYSTERY OF DENISOVA CAVE
Professor John Hawks is an expert on human evolution and a keen blogger. He will bring us all up to date with evidence for and ramifications of interbreeding between humans, Neanderthals and the mysterious Denisovans with his fascinating talk.
Tuesday, July 5, 2011
The phoenix rises from the ashes, the coelacanth from the ocean!
- I felt the need to re-focus my efforts on my "day job" in bacterial pathogenomics rather than devote myself to things Darwinian and evolutionary
- I also did somewhat max out on Darwin and evolution during the Darwin bicentenary year.

Neanderthal jigsaw puzzles
- Could life play fairy chess?
- Darwin's smelly rude bits
- Darwin's Descendants: a Legacy in Science and the Arts
- 2009, Tom Paine's Remains and Darwin
- Dispatches from the cutting edge of flagellar biology part 2 and a half
- From Darwin and Lincoln to Obama: Freedom Evolves!
- Ten myths about Darwin and his theory of evolution
- David Hume's influence on Charles Darwin
- جميع الرجال الاخوة כל הגברים הם אחים
Friday, April 3, 2009
Celebrating Matthew Boulton in 2009
2009 is not just the bicentenary of the births of Charles Darwin and Abraham Lincoln and the death of Thomas Paine, but also the 200th anniversary of the death of Matthew Boulton, the English manufacturer, Lunar Society member, Fellow of the Royal Society and close friend of Charles Darwin's grandfathers, Erasmus Darwin and Josiah Wedgwood. Friday, November 7, 2008
Evolution, education and the University of Birmingham
The Guardian video podcast Teachers TV has just released an interesting documentary The creationism controversy in the classroom on the teaching of evolution in British schools, available via The Guardian website or via iTunes.I was particularly pleased to see colleagues from the my own university, the University of Birmingham, Jerry Pritchard and Susannah Thorpe, taking a prominent role in the video. And the skulls you see are the same skulls that Susannah let me use in the videos from The Origin of Species in Dub!
In fact, as Jerry has pointed out to me, the links between our university and Darwin's time go deep: Thomas Huxley laid the foundation stone of Mason College, which was the forerunner of our university. Huxley's speech on opening the college makes for interesting reading, stressing the importance of a scientific over a classical education, but curiously, towards the end, making a plea for sociology to be taught at the new institution. The last lines should be brought out at every graduation ceremony:
"In conclusion, I am sure that I make myself the mouthpiece of all present in offering to the venerable founder of the institution, which now commences its beneficent career, our congratulations on the completion of his work; and in expressing the conviction that the remotest posterity will point to it as a crucial instance of the wisdom which natural piety leads all men to ascribe to their ancestors."
In fact, we have Darwin built into the very fabric of our university, in that he is one of a handful of figures from the history of Western Civilization to stand above the entrance to the University's most imposing building, the Aston Webb building. But again, I can find no information anywhere on the University's web site as to who decided to put Darwin there and why or who created the statue and how, which is surprising given that the university has badged 2009 the Year of Darwin! Tuesday, September 2, 2008
Darwin's Descendants: a Legacy in Science and the Arts

I am starting to turn my mind to organising next year's Darwin Day in Birmingham--the big one, for Darwin's 200th birthday. So far, I have Dover trial journalist Lauri Lebo pencilled in as one of the star attractions, but will sort out a fuller programme in the next week or two.
DARWIN’S DESCENDANTS
A legacy in science and the arts
Thank you.
In my experience, people want Darwins to be scientists and they want to think that there’s a gulf – even an opposition – between scientific and artistic practice. But of course it’s not as simple as that. When my third cousin, the classicist and poet Ruth Padel, took her biologist mother Hilda to a poetry reading, Hilda said afterwards, ‘I see the point of poets now. They notice things.’ Hilda’s own mother Nora Barlow was a botanist: that respectably feminine outlet for scientifically-minded women in the 19th century. Nora’s cousin Gwen Raverat, the artist and wood engraver, who was born three years after her grandfather Charles Darwin’s death, wrote the classic memoir of growing up as a Darwin, Period Piece[i]. She, too, linked her creativity to a scientific kind of noticing that you will all recognise: observing that ‘The whole of a long life is spent learning to see, to know what one is looking at with one’s inner mind: not in gaining experience, but in losing it.’[ii]
But that’s at the most abstract level. More generally Darwin’s children were great readers, and individually appreciated music and the visual arts to some degree, but on the whole the atmosphere Gwen describes as ‘benevolently Philistine’. Her father Sir George Darwin was Plumian Professor of Astronomy at Cambridge, and she wrote of him and her four uncles:
They were apt to regard the arts as the inessential ornaments of Life: unimportant matters. But this is a superficial view of them: in their scientific work they showed many of the characteristics of the creative artist: the sense of style, of proportion; the passionate love of their subject; and, above all, the complete integrity and the willingness to take infinite trouble to perfect any piece of work.[iii]
Charles and Emma Darwin’s own children were of course descended from Wedgwoods through both parents, and Emma, it should be remembered, took piano lessons from Chopin and was brought up in an family as concerned with aesthetics as with science and industrial production. But as Gwen Raverat put it:
Darwins never cared enough about Art or Fashion, to be much interested in what was Right and Highbrow. When they bought an armchair they thought first of whether it would be comfortable and next of whether it would wear well; and then, a long way afterwards, of whether they themselves happened to like the look of it.[iv]
Of the other four sons, William became a banker, and Frank a botanist and his father’s biographer. Horace was a Major in the Royal Engineers, much involved with scientific projects, and later became President of the Royal Geographical Society, just as many a Darwin in both arts and sciences has gravitated towards the administration of their discipline. Leonard was an engineer whose odd little enterprise, known in the family as ‘The Shop’, became The Cambridge Scientific Instrument Company. Only Bessy, the traditional unmarried daughter, who seems to have had some kind of specific learning difficulty, made no professional mark on the world. Her older sister Etty – Henrietta – edited her father’s The Descent of Man[v] as well as her mother’s letters[vi] and private papers. In fact I have her to thank for my own name, as those latter two volumes were by my mother’s bed when I was born. Names, too, are part of the family self-consciousness: I tried, and very properly failed, to persuade my non-Darwin husband that a suitable name for our first child would be Erasmus.
And this family self-consciousness, this tendency to inwardness, can’t be denied. There is of course Period Piece, never out of print since it was published in 1952. And Frank’s son Bernard wrote, among many books about golf and sports, a memoir called The World that Fred Made,[vii] Fred being the gardener and co-experimenter with Charles in the laboratory that was the garden at Down. Gwen’s sister Margaret Keynes wrote The House By the River[viii] a history of their childhood home Newnham Grange, which is now Darwin College. Two more recent Darwin descendants, Matthew Chapman[ix] and William Pryor[x], grandsons respectively of the poet Frances Cornford and of Gwen Raverat, have written memoirs of their own, in which – to judge by the reviews – their ancestry appears to weigh heavily on their own lives.
As we move down the generations, the direct influence of Charles Darwin is diluted, but the awareness of the world grows ever greater: the Darwin industry is not going to get any smaller or less obvious as the bicentenary approaches. Another path that later generations have taken is of reflecting on Darwin and Darwinism itself. Matthew Chapman has also published an account of the 2005 Dover Pennsylvania trial of Intelligent Design[xi]. In the footsteps of Frank’s biography of his father, Randall Keynes, one of Margaret’s grandchildren, has written Annie’s Box, about Charles and Emma’s beloved eldest daughter who died aged eleven. He is now active in various Darwin-related projects.
But a closer look suggests that immediate family counts for more than the ever-more distant Ancestor. Of the great-grandchildren, it’s true that my father – a lawyer and diplomat – was a slight aberration in his own family: his four siblings were a crystallographer, an electronic engineer, a biologist and a civil engineer. But maybe it’s not so suprising: their father Sir Charles Darwin was with Rutherford when he split the atom, and while Head of the National Physical Laboratory worked at MIT on the development of radar, and their mother Katharine Pember was a mathematician, and the first female member of the Royal Astronomical Society. But Frank Darwin’s second wife was a lecturer in English Literature at Newnham: their daughter Frances Cornford became an extremely distinguished poet. Her older half-brother Bernard’s daughter Ursula Mommens is still a well-respected ceramicist, aged nearly a hundred, and his son Sir Robin Darwin was an artist and Principal of the Royal College of Art for over forty years. With Frances’s artist son Christopher Cornford as Dean, Robin presided over a notable revival of the College. Christopher’s older brother John Cornford was a poet and radical who was killed early in the Spanish Civil War, while Margaret and Geoffrey Keynes’s four sons follow their father’s combination of writing and biological science in varying proportions.
My own generation, the great-great grandchildren, reflects our Darwin and non-Darwin heredity: the list includes not only biologists, bankers, mathematicians, IT specialists, and a botanical illustrator turned botanist, but also lawyers, historians, musicians, film-makers, poets, a novelist, landscape designers, hospitality managers, and a sheep farmer who may have an unusual profession for a Darwin, but who has upheld another family tradition by marrying an equally Darwinian cousin.
But the traditions aren’t always either an advantage or a joke. The general impression that the whole family has always done good, serious work to the utmost of their considerable ability, has made a fair few of us rebel at some point against doing our homework or turning up at family weddings. Not for us the pride in being the first to go to university, to gain an honour or publish a book: someone’s always done it already, and a lot of the external world knows that too. That external world can even be offensive: I’ve been asked more than once if my novel would have been published were I not a Darwin, or whether I’m ‘obliged’ to ‘believe’ in Evolution.
The family habits of mind can also be a handicap. As Gwen Raverat’s biographer Frances Spalding put it[xii] even personal matters have always been discussed in what Frances Cornford described as ‘…a thoroughly weighing Darwinian manner’. Spalding goes on to say, ‘Behind these debates lay the assumption that family characteristics, such as persistence, intelligence and common sense, would inevitably arrive at an authoritative truth.’ But the truth of art isn’t the same kind of truth, as Gwen and Frances knew better than most. And there’s always a risk that one’s more a-rational, intuitive, un-logical creative processes are broken on the wheel of rational analysis and ruthlessly reasonable thought.
Somewhere in the middle, between those who base their careers on their ancestry, and those who struggle to get out from under it, are those of us who try to bend science and the Darwin industry to our own creative purposes. Ruth Padel, having become deeply involved with ecological issues, uses the Darwin name to gain publicity for her campaign to save the tiger and the ecological system of which it’s the top. My sister Carola Darwin, a singer by profession though originally a Cambridge-educated chemist, is involved in commissioning an opera, Children of Fire, which explores the encounter between Charles Darwin and the inhabitants of Tiera del Fuego. And though it annoys me when reviews of my work talk more about my ancestry than the book – it does happen – you could argue that I dropped myself in it. The thematic core of my novel The Mathematics of Love[xiii] is photography, and the first experiments in using light-sensitive substances to record images were made by Thomas Wedgwood, who died in 1806. The earliest part of my story is set, too late, in 1819. Luckily I also needed a doctor, and with the cavalier attitude to facts that is the fiction-writer’s privilege, used Tom Wedgwood’s brother-in-law, Robert Darwin, Charles’s father, not only to set a broken arm, but to offer the narrator, Stephen Fairhurst, and his artist and print-making friend, Lucy Durward, a personal introduction. In this passage,[xiv] set in a Brussels café, I wasn’t just borrowing my ancestors, I was taking their science, and putting it to my own creative and metaphorical ends.
After a while, I said, ‘Was your journey into Staffordshire a success?’
She nodded, and then words came to her tongue. ‘Indeed it was. They were most welcoming. Mr Wedgwood had taken the trouble to come back from his works at Etruria early only to show us his brother’s work – sun-pictures, he called them. My father and I were fascinated, although it was not easy to make out the images, for they must be kept in the dark, lest they darken further, and may only be looked at by candlelight. Mr Wedgwood explained how his brother brushed paper or white leather with nitrate of silver – in solution, you understand – and then the object to be copied was place on top of it, and the whole put in the sun. It took only a few minutes, he said, if the sunlight was strong enough.’ She pulled her chair close in, propped her elbows on the table, and continued. ‘You see, the nitrate of silver tarnishes by the agency of light, where the object does not protect it, even to the degree of translucency of each part of the object’
‘Rather as, when one lifts a long-fallen apple from the lawn, it leaves its mark in the pallor of the grass below.’
‘Yes! And of course, once the grass is again exposed, like the paper, the light darkens it once more. Only the sun-pictures are done in a matter of minutes, and they are so exact! Mr Wedgwood showed us one of a vine leaf. Every vein and stem was as clear as if I had drawn it, only white, of course, on a darkened ground, like a white-line wood engraving. My father was mainly interested in the precision of it, for he has an idea of copying prints automatically by such a process, but it was so beautiful, too! There were some pictures of insect wings, made through a sun microscope so that they appeared larger than in life. I almost feared that they would float off if I breathed too close.’ She paused, as if the mere recollection caused her to stop her breath.
‘And your sister, she accompanied you?’
‘Yes, but she stayed in the drawing room with Mrs Wedgwood and some of her daughters. She said they were charming, very easy and unaffected. But she could tell you more of them than I.’ She drank a little wine. ‘My father was disappointed because although Mr Thomas Wedgwood did try to copy prints with a camera obscura, time blurred the picture. My father and Mr Wedgwood agreed that there being so many difficulties precludes any profitable application of the process.’
I refilled both our glasses. Even Miss Durward’s concentration in drawing had quite a sober quality; I had not seen her face so animated for some time. ‘Tom Wedgwood tried muriate of silver too, his brother said, which turns pale lavender, and violet at the darkest, and in a matter of seconds even in twilight. But it is not so readily applied, because it is not soluble in water.’
A clatter from the back of the café made me aware that the waiter was lifting chairs onto tables, and that most of the other customers had departed. Miss Durward looked around her. ‘Goodness, it must be late.’
‘We should perhaps make our way back.’
‘I suppose we should,’ she said.
I signalled to the waiter and paid the reckoning. As we left the café she said, ‘The strangest thing was, to be able to make a picture of something real with no intervention – no agency – except the natural properties of the sun. The object creates its own image. Mr Wedgwood referred to the image as a simulacrum – a replicant. And then suddenly it has an independent life.’
‘It is like a ghost,’ I said. ‘The object is – may be – long lost, in another time. Its image lives on, in a different place – ’ I could not continue, for suddenly the image of my own love was too clearly before me for speech to be possible.
‘Yes,’ said Miss Durward. She tucked her hand into my arm, and I felt the thin firmness of her through my sleeve. ‘But only when it is kept in the dark.’
Thank you
© Emma Darwin 2008
[i] Raverat, G., Period Piece, London, Faber and Faber, 1952
[ii] Quoted in Spalding, F., Gwen Raverat, London, Harvill, 2001, p.viii
[iii] Raverat, G., Period Piece, London, Faber and Faber, 1952, this edition 1987, p.188
[iv] Raverat, G., Period Piece, p.126
[v] Darwin, C., The Descent of Man, London, John Murray, 1882
[vi] Litchfield, E., Emma Darwin: A Century of Family Letters, London, John Murray, 1915
[vii] Darwin, B., The World that Fred Made: an autobiography, London, Chatto & Windus, 1955
[viii] Keynes, M., The House by the River, Cambridge, Darwin College, 1976
[ix] Chapman, M., Trials of the Monkey: an accidental memoir, New York, Picador, 200
[x] Pryor, W., Survival of the Coolest, Clear Press, 2003
[xi] Chapman, M., 40 Days and 40 Nights: Darwin, Intelligent Design, God, OxyContin, and Other Oddities on Trial in Pennsylvania, New York, Harper Collins, 2007
[xii] Spalding, F., Gwen Raverat, p.162
[xiii] Darwin, E., The Mathematics of Love, London, Headline Review, 2006
[xiv] Darwin, E., The Mathematics of Love, London, Headline Review, 2006, p. 137 (adapted)
Friday, August 15, 2008
Birmingham, England now relocated to the Bible belt
Sunday, August 3, 2008
Ginger genetics
On Friday my attention was drawn to this short film on the advantages and disadvantages of being ginger, made by Helen Cooper (one of my colleagues at the University of Birmingham) and Nick Rutter.
My reactions to the film are mixed. It certainly kept one’s attention and was entertaining throughout. I worry that in re-hashing prejudices against redheads, it might help fuel them—but in that case English comedian Katherine Tate could be held guilty of the same crime:
The film certainly stimulated my interest in the question “why ginger hair?” And in broad terms the science seems OK, pointing out a paradox (why do the ginger genes survive in the face of social stigma and an increased susceptibility to skin cancer) and sketching out three kinds of potential evolutionary explanation: sexual selection, genetic drift and natural selection. The film leaves out any detailed consideration of the other kind of answer to the “why ginger hair question?”, i.e. a mechanistic genetic explanation of the phenomenon—but one can only go so far in a six-minute film!
In fact, the explanation has been clear for over a decade. Ginger or red hair appears in people who have two copies of a recessive gene that encodes a mutant form of the melanocortin 1 receptor (MC1R) protein, a protein which regulates the production of various forms of the skin and hair pigment melanin. Over sixty different mutations that affect the function of MC1R can cause variously grades of red-ginger hair, usually accompanied by pale skin, freckles and a tendency for skin to burn rather than tan after exposure to sunlight—for an excellent introduction to the genetics of MC1R, see the relevant article from OMIM (Online Mendelian Inheritance in Man). Interestingly, a study published in May this year showed that red-headedness is what geneticists call the null phenotype in human, i.e. is what you get when you have no functioning MC1R at all.
The ginger complexion is very rare in humans, found in less than 1% of the world population. It is common in the North West of Europe, with the highest rates in Scotland and Ireland. As a result of Scots and Irish migration to the New World, the largest number of ginger-haired people occurs in North America; there are also many in Australia. A few years ago, during a trip to the Northern-Irish city of Derry/Londonderry, I visited a million-pound high-tech exhibition called “The Fifth Province” which is housed within the city’s Calgach centre. The exhibition focuses on the Irish Diaspora and features a series of Irish, North American and Australian ginger-haired freckled children as proof of a common Irish heritage. In fact, in Irish step dancing competitions, according to a friend from Northern Ireland, marks are awarded for how “Irish” girls look and the ginger complexion is considered so authentically Irish that girls often wear ginger-haired wigs.
Curiously, in Jamaica, native-born white people are usually termed “red men” by the rest of the population— a fact brought home to me earlier in year when Karen Nelson, a Jamaican-American expert on bacterial genomes, was introduced via e-mail and photo to my collaborator on the Origin of Species in Dub, Jamaican geneticist Dominic White (who has a Northern-Irish mother and Jamaican father). Her first comment was how “red” he looked!
But even more curiously, in Jamaica there are people from the self-identified black community, who have reddish hair, freckles, and a rusty complexion (they are sometimes called “red Ibos”). A study from the University of the West Indies has confirmed that this complexion is linked to mutations in MC1R.
Let’s now examine the claims in the film in more detail.
First of all, the idea that the genes for ginger hair and the ginger phenotype are destined to die out soon appears to be an urban myth/persistent meme that has little or no basis in reality. This topic has been explored repeatedly in the blogosphere:
- http://www.kqed.org/quest/blog/2008/03/31/redheads-are-here-to-stay/
- http://scienceblogs.com/gnxp/2007/08/red_hair_going_extinct.php
- http://scienceblogs.com/gnxp/2007/08/update_on_redhead_hoax.php
Working through the film’s explanations for ginger hair in reverse order…
What about the claim that ginger hair and pale skin provide a selective advantage by facilitating the synthesis of vitamin D in the skin? The idea that the pale skins seen in Europeans are the result of selection for increased vitamin D production (a process driven by UV radiation from the sun and masked by melanin) has been around for several decades, but is still the subject of some controversy. However, I can find no evidence in the scientific literature that specifically links increased vitamin D production to the ginger-haired phenotype rather than simply to European-style pale skin in general.
In addition, there is no evidence from molecular genetic studies to suggest that natural selection has been acting on the MC1R mutations associated with red-headedness. In fact, the opposite appears to be the case: in Africa at least natural selection seems to be acting to preserve the original dark-skinned dark-haired version of the gene. However, as an interesting aside, Darwin reported in The Descent of Man a claim that redheads were the best suited of all Europeans to working in an African environment!!
The second explanation discussed in the film, a relaxation in the selective pressure to maintain the original genotype in high latitudes, appears to be most likely according to genetic studies. In other words, what is not forbidden by natural selection is allowed.
One objection to this neutralist explanation is that the ginger phenotype is associated with an increased risk of skin cancer, so one would expect it to be selected against. A counter-argument here is that such cancers typically occur after reproductive age and so will not affect reproductive fitness. However, when discussing similar arguments on pale skin more generally, Jared Diamond has pointed out a counter-counter-argument—that in human societies individuals might still contribute to the fitness of genes in their descendants long after birth of their children (the what-use-is-a-grandmother argument)
What of the first explanation: sexual selection? As pointed out in the film, this was the explanation favoured by Darwin in the Descent of Man for differences in human skin colour and in this context has recently been re-visited in a review article by Aoki (which I have not been able to obtain: can anyone e-mail me a PDF?). The folk wisdom is that redheadedness is attractive in a woman, but unattractive in a man. But I can find no papers that attempt to document or quantify the attractiveness of ginger hair colour or that describe any mathematical model that would explain current gene frequencies through an interplay between the negative effects of natural selection and female-specific positive effects of sexual selection Perhaps, someone out there can start a collaboration between psychologists, geneticists and mathematical modellers that would deliver the ultimate truth on this tricky question!
And before closing, let me throw in two final pertinent points.
Firstly, ancient DNA studies on Neanderthals have shown that provided evidence that at least some Neanderthals had MC1R mutations that although not seen in modern humans, probably resulted in red hair.
Secondly, our close relatives the orangutans have ginger-red hair, provoking the two “why” questions:
- Why in genetic terms? These apes have been shown to have a functional MC1R, suggesting that the mechanism of red hair generation in orangs is different from the prevalent mechanism in European human populations. One hopes that the orang genome sequence will soon deliver the answer.
- Why in evolutionary terms? Sexual selection again? Or genetic drift? But as they live in the Tropics, one might argue that the selection would favour a darker complexion?
Clearly, the evolution and genetics of red hair will keep scientists busy for a few more years yet!
Further Reading
The wikipedia article on red hair is surprisingly informative. Also there is a recent book on this subject (although I have not read it).